The Latest upgrade to 'FL21.0.1.3348-Win10-64' (2022-12) runs as usual in a Win 10 Bottle. The new stock effects seem to work very well, too.
Text input in dialog boxes (eg. Imputing a Pattern Names, etc) has some glitches in recent versions (not sure when this appeared). Pressing backspace while typing closes (sometimes cancels) the dialog box immediately. It is not a serious problem for me, and I've ignored it until now. I thought that editing one of the graphics settings in the Wine Configuration might solve it, but that doesn't do it. Still a very small annoyance.