To install, I made sure that I had already made a bottle with .Net 3.0 Redist in it and installed the game into this bottle.
The game runs great for me other there being shadows everywhere on the lower rendering settings.
An FYI - the settings window isn't great, so the best way I found to change the settings is in User/Documents/Fifa 11 and fifasetup.ini (use BBEdit or something)
(I'm on a MacMini with a 256MB NVIDIA GeForce 9400M)
NUMBER_SPEAKERS 2 (5 made the commentary bad)
RENDERINGQUALITY 0, 2, 3, 4 (For 2& 4 I received an error, but the game played - which it didn't for 1 as the game didn't load. For 3 it worked just fine) - Rendering increased in quality as the number was increased.
WAITFORVSYNC 0 (For 1 I got an error, and the game didn't play)
MSAA_LEVEL 0, 1, 2
for Aspect Ratio and resolutions, use your head. They didn't cause any crashes or anything if I changed them.