The game would work perfectly, because its the same engine as fallout 3. But there is a problem to start the game. Launcher works, you can change settings but if you start the game this error appears: "Failed to initialize renderer. Unknown error creating the Gamebryo Renderer.".
This game also doesn't start under latest wine. There is a workaround in wine, but you need a git installation. No idea how to apply the patches under crossover...http://appdb.winehq.org/objectManager.php?sClass=version&iId=21692&iTestingId=57981