Fallout 4 Forum

So, there's a different means to get the GOG.com version of Fallout 4 Running. This fix involves going into the Fallout.ini and the Fallout4prefs.ini and editing the text to get optimal settings for the game!

Here is some additional tweaking for older Macs while installing and running Fallout 4 on Crossover 24. Separated in Parts

Preferences (These are found in the Folder for Fallout 4. They could be found in the folder "Documents/My Games/Fallout 4", These documents are .txt or text files, and can be edited with textedit, or some kind of text app that handles ".txt" or ".ini " files.

First go for the file titled, "Fallout.ini"

Inside the Fallout.ini file, look for the item, "bBackgroundMouse=0" or "bBackgroundMouse=1" under the heading labeled "Controls". If it's already written as "bBackgroundMouse=1" the setting is correct, if there is no phrase bBackgroundMouse at all, then enter "bBackgroundMouse=1" without quotations.

Second go to the file titled, "fallout4prefs.ini" to check and edit graphics settings.
Check and edit the items in this document. If they aren't already set as follows, edit them to the correct setting.

"iSize = " should read out as your native monitor resolution. In my case, it's 1440 x 900, but check your machine's native resolution to see if it's different.

"bBorderless=1", "bMaximizeWindow=1", "bTopMostWindow=1", and "bFullsscreen=0" are the remaining preferences which should either already be set or edited to read as follows by you.

Launcher (The Panel Which Opens when you Launch Fallout 4)
Set the "advanced gfx" option to low and set the "Godrays" option to "None"

With these options taken care of, the game should run far better.

Here's an addendum, also found within the "Fallout.ini" file. Open the file and go into the heading of [General]. In that heading, add the line, "bDisableAllGore=1" (Without Quotes), this greatly reduces crashes related to the graphics processing the combat and post-combat graphics. Also take care of the preferences by going into the Advanced Preferences in the Game Launcher and clicking Godrays off. The Godrays causes crashes on various graphics settings in both the GOG.com and Steam versions of the game.