Edit/Open with TextEdit:
/Users/xo22/Library/Application\ Support/CrossOver/Bottles/[YOUR BOTTLE NAME]/drive_c/users/crossover/Documents/My\ Games/Fallout4/Fallout4.ini
Change:
[Audio]
bEnableAudio=0
(Default is =1)
...and it runs.
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Edit/Open with TextEdit:
/Users/xo22/Library/Application\ Support/CrossOver/Bottles/[YOUR BOTTLE NAME]/drive_c/users/crossover/Documents/My\ Games/Fallout4/Fallout4.ini
Change:
[Audio]
bEnableAudio=0
(Default is =1)
...and it runs.
It will run, and runs great with Crossover 23.5 on my M1 Pro; however, no in-game sound after the video at the beginning. The DLL overrides mentioned at AppleGamingWiki do not fix the problem.
CrossOver Forums: the place to discuss running Windows applications on Mac and Linux