For a very long time now I've had certain issues with Fallout 3, and now that I've finally found the time to do some proper testing here's what I've found:
Everything appears to work to begin with (except music on the pip-boy radio which doesn't play properly; it seems to work in Wine-Staging 1.7.50 using POL although I only gave it a brief test there) but after playing a while there starts to be some graphics corruption - I've found a reliable way to trigger this is to start blowing up vehicles (I have a "lucky" savefile that's good for testing this, where I encountered the firelance random event near the supermarket).
First there will start to be a bit of graphics corruption happening during big explosions. After this happens using a stealth boy will result in constant graphics corruption for the duration of its effect and the edges around water start to appear very dark.
Explosion- http://imgur.com/SskYbZS
Water- http://imgur.com/jCfS73r
Stealth boy- http://imgur.com/ZVFcJFS
Once that initial graphics corruption starts occurring, another frequent problem is for the HUD & postprocessing effects to disappear when facing certain directions. I have discovered that taking a screenshot using ksnapshot sometimes seems to fix this particular issue, at least temporarily - but only while running the game in a virtual desktop and only when running the game below 1920x1200 (my monitor's native resolution).
Now you see the HUD- http://imgur.com/LUD5mia
Now you don't- http://imgur.com/pxakLZ6
Resolution appears to be a factor here- I have tested at 1440x900, 1680x1050 and 1920x1200. The problem occurs irrespective of virtual desktop being enabled or not (and irrespective of running in windowed mode or not) but only seems to occur at higher resolutions - or if it does occur at lower resolutions then it needs much more time than I tested.
There is also some consistency as to how soon these graphics issues occur... every single time I've tested this at 1680x1050 I can destroy 5 vehicles before getting graphics corruption with the 6th. At 1920x1200 it begins immediately with the first vehicle I destroy.
So far I have been testing the game with everything maxed out. I now intend to start dialling the settings back & seeing what happens.
System specs:
Linux Mint 17.2 KDE 64-bit, CrossOver 14.1.6
i7-2600k 4.4GHz
16GB RAM
Nvidia GTX 970 (proprietary driver 346.82)