The test system for this game was a 2 Ghz Core 2 Duo MacBook with 3 GB RAM, running 10.5.8 and CXG 8.1.4. Past advice on how to get the game to install and run effectively as posted here seemed to work, only that after installing the unofficial Fallout 2 Restoration Project patch, Fallout 2 would only run in a win98 bottle.
The problem I've encountered here is that performance is horrible. The mouse is very jerky, and the game itself is extremely slow. I've tried disabling USB Overdrive but that doesn't seem to have much effect. I'm baffled that others have gotten such good results while the game continues to perform very slowly for me.