Using a NOCD Patch, I got this game to actually enter the tutorial, but part of the event queue system seems to be affected by Crossover, as it just sits there when you (The Evil Genius) should be flying in via helicopter. The interface and navigation works, but without the event queue, the game doesn't proceed.
Entering the main game, it starts bringing up the interface and scenery (it's dimly visible) but freezes with a non-standard mouse cursor. I would guess again that some part of the event queue system is broken here as well.