DxO Optics Pro 8.5 Forum

You need to install the .net 40 package first.
Refer to Photomatix 5 instructions for more details.

Update:
Install these packages in a winxp bottle:
.net 40
gdi+
msxml6
corefonts

Then install DxO. This works for Pro 8.5. You can start it, download modules (very slow!) and start processing.
There is no progress shown for the processing and it appears to never end, but only consume CPU endlessly.
The console output looks like this:

WINEDEBUG=all "/opt/cxoffice/bin/wine" --bottle "dxo" --check --wait-children --start "C:/users/crossover/Desktop/DxO Optics Pro 8.lnk"
INFO [DxOFramework] Running oclcheck with cache file: C:\users\crossover\Local Settings\Application Data\DxO_Labs\DxO Optics Pro 8\ocl32.cache...
INFO [DxOFramework] Loading ocl cache file: C:\users\crossover\Local Settings\Application Data\DxO_Labs\DxO Optics Pro 8\ocl32.cache
ERROR [DxOFramework] Binary is empty
INFO [DxOFramework] CPU performance: 68.73
INFO [DxOFramework] Final test already done => DoneAndFailed
INFO [DxOFramework] OpenCLDeviceCache Dump :
cpu perf : 68.7317
init test result : DoneAndFailed
list of device :

INFO [DxOFramework] Done oclcheck SUCCESS.
Query returns not positive
wine: Call from 0x7b83d472 to unimplemented function windowscodecs.dll.WICMapShortNameToGuid, aborting
wine: Call from 0x7b83d472 to unimplemented function windowscodecs.dll.WICMapShortNameToGuid, aborting

PS. I had to install winbind for it to work in vanilla wine, but I'm not sure if it's necessary for crossover.