The game installs and plays very well. Only 2 things to keep in mind:
a: When installing the game, use the option to pick your own installer and use Setup.exe off the CD.
b:
The Digital Rights Management (DRM) software in this program
prevents it from running in CrossOver. If you are in a legal jurisdiction
which allows removal of such software, you may have luck running this
program. Unfortunately, CodeWeavers, because they are subject to the
Digital Millennium Copyright Act, will be unable to support you.
Duke Nukem: Manhattan Project will now play FLAWLESSLY!