Sorry for the thread title, couldn't resist.
The game almost works perfectly on my Macbook Pro Retina - the only issue is the sprites flicker and glitch. The 2D Characters appear scrambled as they animate.
The folks over at PortingTeam.com are experiencing a similar issue with their wineskin wrappers - maybe this is related?
http://portingteam.com/topic/9534-req-ducktales-remastered/
Can anyone else verify the problem on OSX?