Just a beware to those who want to try what I did - you can't install the cd-rom release.
First of all, trying to install from disc requires you to install it as an "Unlisted application" - the existing entry for Doom 3 assumes you have it on Steam.
Second, it has multiple discs, and trying to "Eject" a disc in CrossOver in order to install another one won't work (it just says "are you sure?", then nothing happens).
Third, trying to make images of the discs won't work either - when mounting you are told it can't find any file system to mount. I've tried both Disk Utility using "DVD/CD master" and dd in the terminal. I assume this has something to do with DRM, but I'm not savvy enough to know the gritty details.