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As has been mentioned before you need to run diablo in 32bit mode for video to work right. When running in 32bit mode you may see where the curser disappears or in full screen mode the curser is not lined up with where it clicks. You can also loose keyboard input if not in full screen. In these cases you most likely have dual monitors which causes the input issues. Set the game to run on a virtual desktop of your chosen resolution.
Using virtual desktop has been the most reliable way to run Diablo III. I haven't had any issues with mouse/keyboard input since doing this. The only issue I come across now is pressing Alt to see items on the ground, and then clicking on the item grabs the window to move it. I can probably just re-assign that keyboard mapping to use Meta or something.
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