This issue seems to still be present in 8.0.
thoht@laptop:~$ wine .wine/drive_c/Program\ Files/Deus\ Ex/System/DeusEx.exe
fixme:process:GetProcessWorkingSetSize (0xffffffff,0x32f38c,0x32f384): stub
X Error of failed request: GLXBadDrawable
Major opcode of failed request: 154 (GLX)
Minor opcode of failed request: 5 (X_GLXMakeCurrent)
Serial number of failed request: 772
Current serial number in output stream: 772
This results in the game splash screen being displayed, which freezes. Nothing else happens so eventually I kill it with xkill.
thoht@laptop:~$ wine .wine/drive_c/Program\ Files/Deus\ Ex/System/DeusEx.exe
fixme:process:GetProcessWorkingSetSize (0xffffffff,0x32f38c,0x32f384): stub
fixme:win:EnumDisplayDevicesW ((null),0,0x32c8b8,0x00000000), stub!
err:ddraw:PixelFormat_DD2WineD3D 16 bit RGB Pixel format does not match
err:ddraw:PixelFormat_DD2WineD3D 32 bit RGB pixel format does not match
err:ddraw:PixelFormat_DD2WineD3D Invalid dwRGBBitCount in Pixelformat structure
err:ddraw:PixelFormat_DD2WineD3D Invalid dwRGBBitCount in Pixelformat structure
err:ddraw:PixelFormat_DD2WineD3D Invalid dwRGBBitCount in Pixelformat structure
fixme:keyboard:RegisterHotKey (0x30046,49243,0x00000001,27): stub
err:ole:CoGetClassObject class {92fa2c24-253c-11d2-90fb-006008a1f441} not registered
err:ole:CoGetClassObject no class object {92fa2c24-253c-11d2-90fb-006008a1f441} could be created for context 0x1
err:ole:CoGetClassObject class {d8f1eee0-f634-11cf-8700-00a0245d918b} not registered
err:ole:CoGetClassObject no class object {d8f1eee0-f634-11cf-8700-00a0245d918b} could be created for context 0x1
fixme:dsalsa:IDsDriverBufferImpl_SetVolumePan (0x1be9d8,0x1be960): stub
fixme:dsalsa:IDsDriverBufferImpl_SetVolumePan (0x1be9d8,0x1be960): stub
fixme:dsound:DllCanUnloadNow (void): stub
Here the game launches the configuration window since it didn't shut down properly last time it ran. I choose the Direct3D Support and launch the game which causes a series of screen jerks and in most cases it also kills the X server. This ONE time it didn't, I'm not sure as to why. I run the game with the default settings. It ran just fine in Wine 1.0.1, but later releases of both Wine and CX seems to have this issue.
On a perhaps not entirely unrelated note, Diablo II which ran nicely in Wine versions prior to 1.0.1 (after which it couldn't be installed due to Gecko problematics) now runs really, really slow. Also compared with default settings.