Briefly:
Game runs well enough on the M1, but (in my experience)
... gets laggy when multiple characters running around (fight at the park in Hell's Kitchen good example)
... gets laggy when hacking computers
... seems not to like Hong Kong (crashes, but not yet tested replicability of these)
The updated "Deus Ex revision" is unplayably laggy as soon as any character appears, e..g when the security bot walks into frame on liberty island docks... even the seagull doesn't fly smoothly. Which is a shame.
Seeing much better performance on a 6-yr-old MBP under the same version of Crossover (21.1).