OS is Mac OS X 10.8.3
Defiance installed in a Windows XP bottle. Patcher works, and can update the game.
Client starts, shows splash screen, tries to connect to game server, and immediately fails with a "Defiance service is not available" message. Retrying again immediately fails.
Seems to be a problem on the client side, since the normal behavior would show an activity spinner for a few seconds until a connection is established to the game server.
Seen other reports of this, such as this thread.
Have unsuccessfully tried with Crossover Mac 12.1.2, 12.1.1, and 12.1.0, and also with wine 1.5.27 (using suggested wine tricks mentioned at their AppDB Defiance page).
The game is playable with Parallels Desktop, so it doesn't seem to be a network/firewall issue that's causing the problem. Would like to play it with CrossOver for better performance.