The game installs without a hitch and runs fine with a no-cd patch.
Your hands, equipment and weapons are unfortunately invisible, this wreaks any sense of immersion in the game and makes the forensic puzzles nigh on impossible to complete.
I have not been able to find a solution to the problem online.
It is a registered bug at winehq.
System:
Macbook Air (Late 2010)
OS X Mountain Lion 10.8.4
Intel Core 2 Duo (2.13 GHz)
4 Gb RAM
Nvidia Geforce 320M
Crossover 12.5