OS: Snowleopard
Graphicscard: NVIDIA 9400M
GOG.com version:
I tested the GOG.com version of Commandos 3 (version 1.43): Destination Berlin which comes together with Commandos 2: Men of courage (version 1.20) for $9,99. Bought it in promo for $4,99. This version contains no CD copy protection so runs right out of the box. So if you have/use the CD version you might have to update to version 1.43 manually. Besides that i don't know (but probably will), that there might be CD copy protection on that CD (DRM), so realize that.
CD version:
After installation, patch to the newest version. The game contains CD copy protection, so you have to deal with that to play the game.
What says WineHQ?
Read it all here...
Have fun!