I believe that I am indeed running the most recent version (although it is the Trial version, though I don't think that should make much of a difference)
Occasionally, when running through the "Run Command" window, it will bring up the initialization screen (the installsplash.bmp picture), but will fail after that.
Wine is apparently loading a debugger, but none of the Debug Options seem to be able to turn it off.
When I have it save a log, this seems to be the problem (it comes up twice, both of them after the third time it starts generals.exe (starting 'Applications/CrossOver Games.app/... /generals.exe')):
wine: Unhandled page fault on read access to 0x2eb00054 at address 0x650b20 (thread 001b), starting debugger...
Unhandled exception: page fault on read access to 0x2eb00054 in 32-bit code (0x00650b20).
err:dbghelp:pe_load_msc_debug_info -Debug info stripped, but no .DBG file in module L"secdrv.sys"
(It then does a Register Dump)
wine: Unhandled page fault on read access to 0x00340061 at address 0x407620 (thread 001d), starting debugger...
Unhandled exception: page fault on read access to 0x00340061 in 32-bit code (0x00407620).
(It then does another Register Dump)