Just got my hands on a copy of ChemDraw 10.0 and tried to install it under the latest CXO to no avail. The installation dies after the "WinZip Self Extractor" stage, and this time, having Internet Explorer and DCOM95 installed beforehand didn't seem to help matters any. Tried installing in new Win2000 and Win98 type bottles and neither worked. I'm stumped, but I'll keep trying.
In the meantime, stick with ChemDraw 8.0, which works fine (mentioned elsewhere on these pages).