Here's what I did to get this installed and working.
Install the following in a Windows 7 bottle:
-Microsoft .NET Framework 4.0
-Microsoft Visual C++ 2013 (12.0) Redistributable Runtime
-Platform SDK Redistributable GDI+
Install the ChemDraw executable (cdpf150.exe).
When the installer window comes up (as with previous versions) "Install Software" will not do anything, but "Explore This Disc" will allow you to locate (under CambridgeSoft/ChemOffice/) the installer file CambridgeSoft_ChemDraw_Professional_15.0.msi. Click on that to install.
What I know works:
-Reading & writing .cdx files
-Saving .png files
-Saving .mol files
What kind of works:
-Saving .svg files (some corruption in text alignment)
What does not work:
-NMR prediction (cannot find a file)
-SciFinder link