After many many hours in game I have yet to see a single problem. However getting the game to run was not as smooth.
I installed the game using the Crosstie. On first start I had all sorts of issues. A virtual desktop was displayed but no windows opened. I edited the battle to not use a virtual desktop. Second start was better the first with the patcher launched but after a few seconds the patcher would crash.
I d/l the latest game on a windows machine and moved the files to the created bottle and relaunched. The game starts and plays flawlessly.
I suspect that DCUO and Champions will see an increased population with the planned shutdown of City of Heroes/Villians.