I was surprised to see a rating of "Known not to work" for this game. It's possible that it will fail for me later on in the game. I'm only near the end of level 1. However, I didn't have to do anything special to make this game work for me. I'm running the Mac version of CrossOver Games 8.0.0 though Bookworm Adventures Deluxe also worked in 7.2.2 for me.
The initial animation of the worm chomping on the letter blocks is choppy, but the actual gameplay is quite fluid. After seeing how well it played in CrossOver Games, I purchased it from PopCap.
Unlike other programs that required me to find native DLLs in order to get the program to function, this one was very simple. Hopefully, in time, other PC games will be this easy to install in CrossOver Games.
Bob C