The launcher requires .net 4.0 and does not work, you can however launch the BIN/WIN32/BlackProphecy.exe directly and manually download and apply the patches with BIN/WIN32/RTPatch.exe
The game itself runs very well except for the mouse can only be used in the menu modes, needs the DirectInput mouse patch applied to Wine.
DirectInput patch: http://bugs2.winehq.org/attachment.cgi?id=33578