Through Crossover, Bioshock 2 Remastered launches, everything loads up and the interface is all useable. The FIRST problem you will run into in Crossover 21.2 is when you launch a new game, it will say "press SPACE to continue", but the space key does not register. Don't worry though, one way I was able to bypass this is with a controller, connect your controller and press the corresponding key to continue. SECOND problem was when you were in the game, the textures were flickery, I was not able to take a screenshot of this because the screenshot did not capture the flickering, but rather a clean image of the game. Everything in the game loads though, no black textures or anything, just flickering.
Crossover Version: 21.2
Mac OS versions tested: Monterey and Ventura
DXVK: Regular version supplied by Crossover
MoltenVK: Regular version supplied by Crossover
Mac Specs: M1