I've noticed a significant improvement in performance with Alan Wake going from CrossOver 12.2.2 to 12.5 - it now runs smooth/at least feels smooth for me even on max settings with only minor graphical glitches (enabling vsync causes it to crash though)... however, sound issues remain. The strange thing is that the sound is intermittent - usually when I start the game I get sound in videos/cutscenes but not menus or gameplay, but occasionally sound will work in the menus and gameplay but not cutscenes, and very rarely it will work fully.
Due to the sound issues I can't consider it playable, but it's almost there...
System specs:
Linux Mint 15 KDE 64-bit
i7 2600k @ 4.5GHz
8GB RAM
Nvidia GTX 570 / driver version 313.30