Just as a quick update, I did a search for "DXVK" from the location Crossover uses as the drive, and came across a AoE2DE_s_d3d11.log
What I get to is:
err: DxvkGraphicsPipeline: Failed to compile pipeline
err: vs : VS_952314f1aa1489ea5b4ec4ca309c8db971d7d68f
err: fs : FS_8eb9b0ba3f5ce577fd47657949effbe20ac27f78
err: attr 0 : location 0, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 0
err: attr 1 : location 1, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 16
err: binding 0 : binding 0, stride 32, rate 0, divisor 0
err: DxvkGraphicsPipeline: Failed to compile pipeline
err: vs : VS_d2c410846d3713e8f4f527a2bd28800888a304a0
err: fs : FS_2b971528ad5105354e9ae6c744a774428e5c4f81
err: attr 0 : location 0, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 0
err: attr 1 : location 1, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 16
err: attr 2 : location 2, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 32
err: attr 3 : location 3, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 48
err: attr 4 : location 4, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 64
err: attr 5 : location 5, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 80
err: attr 6 : location 6, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 96
err: attr 7 : location 7, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 112
err: attr 8 : location 8, binding 0, format VK_FORMAT_R32G32B32A32_SFLOAT, offset 128
err: binding 0 : binding 0, stride 144, rate 0, divisor 0