I have Photoshop CS running, using a hacked together combination of CX 3.0.1 and the itunes preview 3.1.0alpha version.
It looks like the deciding factor is the 'setFilePointerEx' function, which had not yet been implemented in the version of wine in 3.0.1, but is implemented in current versions.
So let's all cheer on the CodeWeavers team to get 3.1.0 ready!