I was able to get the game to install and run just fine. All graphical settings are maxed (except no FSAA or HDR, of course) and everything looks great and runs fairly smooth at 1680x1050. I've started a new game and run around for a bit inside the starting structure and outside. No major signs of instability yet. The only problem is that there is no sound. I'm sure I just need to add some dll's, but I don't know which ones yet. If I figure it out, I'll post the solution here. If anyone else knows the answer, do the same.
I'm running OSX 10.6.1 on a MacBook Pro, 2.5 GHz C2D, NVIDIA 8600m GT, 512 MB VRAM, 4 GB RAM.