I've just completed a play-through on CXGames 10.1 on Max OS X 10.6.7 on a Mid-2009 27" iMac, and had very few problems. This was with the Steam version of KOTOR.
I did have to run winecfg and set 'Emulate a Virtual Desktop' to 1024x768. I also had to turn off 'grass' in the game graphics options.
With this, the game ran smoothly, albeit in a window, at 1280x960, and movies worked perfectly. The only downside is the window will resize for the movies.
The only problem I encountered was a couple of interactivity problems when on the stats screen, where mouse clicks and the keyboard would no longer be recognised. However, this was very rare and for the most part it ran very cleanly.