Like many others, I've gotten Solium Infernum to function without much work on my part. I don't like how full-screen makes a gray border when running in CrossOver, so I forced a virtual desktop of 1024x768 to ensure windowing.
It works rather well. If I remember correctly, the Windows version sports a different font, but that doesn't hinder the game nor does it bother me enough to warrant further investigation.
I'm running CrossOver Games 8.1.4, and I've been able to run every version of SI since the beta.