I'm running DotP 2012 on my 13" MBP with OS X 10.6.8 and CrossOver Games 10.1.2 without many problems. As mentioned in another thread, switching resolutions is a bit of a hassle, but apart from that, the game runs pretty fine. It hangs now and then for a few seconds (usually when a player's turn or a phase of a turn ends), but nothing grave.
The only major problem I have, is that the multiplayer mode does not work at all. Any attempt to find or create a game results in an instant "Connection failed" error.