Seems that DDO is having all sorts of problems with CXG. Just to see if there is any pattern, could those having trouble post answers to these questions?
Did you upgrade CXG 7.x to 8.0? ...or is this a new install?
Did you upgrade an exisiting DDO bottle? ...or is it a new bottle?
Did you copy the DDO files from a windows installation? ...or use a downloaded installer?
What video chipset is in your box?
Linux/OSX?